Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.

Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.

BACKGROUND: RTS,S/AS01(E) is the lead candidate pre-erythrocytic malaria vaccine. In Phase IIb field trials the safety profile was acceptable and the efficacy was 53% (95%CI 31%-72%) for protecting children against clinical malaria caused by P. falciparum. We studied CS-specific T cell responses in...

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Detalles Bibliográficos
Main Authors: Olotu, A, Moris, P, Mwacharo, J, Vekemans, J, Kimani, D, Janssens, M, Kai, O, Jongert, E, Lievens, M, Leach, A, Villafana, T, Savarese, B, Marsh, K, Cohen, J, Bejon, P
Formato: Journal article
Idioma:English
Publicado: 2011

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