Lineage-specific genome architecture links enhancers and non-coding disease variants to target gene promoters

Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major missing link in understanding genome control. Here, we use promoter capture Hi-C to identify interacting regions...

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Bibliographic Details
Main Authors:	Javierre, BM, Burren, OS, Wilder, SP, Kreuzhuber, R, Hill, SM, Sewitz, S, Cairns, J, Wingett, SW, Várnai, C, Thiecke, MJ, Burden, F, Farrow, S, Cutler, AJ, Rehnström, K, Downes, K, Grassi, L, Kostadima, M, Freire-Pritchett, P, Wang, F, BLUEPRINT Consortium, Stunnenberg, HG, Todd, JA, Zerbino, DR, Stegle, O, Ouwehand, WH, Frontini, M, Wallace, C, Spivakov, M, Fraser, P
Format:	Journal article
Language:	English
Published:	Cell Press 2016

Lineage-specific genome architecture links enhancers and non-coding disease variants to target gene promoters

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