Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity.

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity.

Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease separase. Separase also promotes centriole diseng...

Полное описание

Библиографические подробности
Главные авторы:	Thein, K, Kleylein-Sohn, J, Nigg, E, Gruneberg, U
Формат:	Journal article
Язык:	English
Опубликовано:	2007

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