Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes

We have investigated the evidence for positive selection in samples of African, European, and East Asian ancestry at 65 loci associated with susceptibility to type 2 diabetes (T2D) previously identified through genome-wide association studies. Selection early in human evolutionary history is predict...

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Bibliographic Details
Main Authors: Ayub, Q, Moutsianas, L, Chen, Y, Panoutsopoulou, K, Colonna, V, Pagani, L, Prokopenko, I, Ritchie, G, Tyler-Smith, C, McCarthy, M, Zeggini, E, Xue, Y
Format: Journal article
Published: 2014