The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated...

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Chi tiết về thư mục
Những tác giả chính: MacDonald, P, Rorsman, P
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2007
Miêu tả
Tóm tắt:Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in beta-cells at the single-vesicle level.