The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.
Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797068311468441600 |
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| author | MacDonald, P Rorsman, P |
| author_facet | MacDonald, P Rorsman, P |
| author_sort | MacDonald, P |
| collection | OXFORD |
| description | Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in beta-cells at the single-vesicle level. |
| first_indexed | 2024-03-06T22:08:55Z |
| format | Journal article |
| id | oxford-uuid:5121874c-0f0e-4c0e-b343-5d198fbb7b1b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:08:55Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:5121874c-0f0e-4c0e-b343-5d198fbb7b1b2022-03-26T16:17:39ZThe ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5121874c-0f0e-4c0e-b343-5d198fbb7b1bEnglishSymplectic Elements at Oxford2007MacDonald, PRorsman, PExocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in beta-cells at the single-vesicle level. |
| spellingShingle | MacDonald, P Rorsman, P The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. |
| title | The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. |
| title_full | The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. |
| title_fullStr | The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. |
| title_full_unstemmed | The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. |
| title_short | The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. |
| title_sort | ins and outs of secretion from pancreatic beta cells control of single vesicle exo and endocytosis |
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