Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.

We investigated the effects of two mutations in human cardiac troponin I, Arg(145)-->Gly and Gly(203)-->Ser, that are reported to cause familial hypertrophic cardiomyopathy. Mutant and wild-type troponin I, overexpressed in Escherichia coli, were used to reconstitute troponin complexes...

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Hlavní autoři: Burton, D, Abdulrazzak, H, Knott, A, Elliott, K, Redwood, C, Watkins, H, Marston, S, Ashley, C
Médium: Journal article
Jazyk:English
Vydáno: 2002