Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.

We investigated the effects of two mutations in human cardiac troponin I, Arg(145)-->Gly and Gly(203)-->Ser, that are reported to cause familial hypertrophic cardiomyopathy. Mutant and wild-type troponin I, overexpressed in Escherichia coli, were used to reconstitute troponin complexes...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Burton, D, Abdulrazzak, H, Knott, A, Elliott, K, Redwood, C, Watkins, H, Marston, S, Ashley, C
التنسيق: Journal article
اللغة:English
منشور في: 2002