Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.

We investigated the effects of two mutations in human cardiac troponin I, Arg(145)-->Gly and Gly(203)-->Ser, that are reported to cause familial hypertrophic cardiomyopathy. Mutant and wild-type troponin I, overexpressed in Escherichia coli, were used to reconstitute troponin complexes...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Burton, D, Abdulrazzak, H, Knott, A, Elliott, K, Redwood, C, Watkins, H, Marston, S, Ashley, C
Materialtyp: Journal article
Språk:English
Publicerad: 2002