The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. IDH1/2 normally catalyse the oxidative decarboxylation of iso...

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Dettagli Bibliografici
Autori principali:	Carbonneau, M, M Gagné, L, Lalonde, M, Germain, M, Motorina, A, Guiot, M, Secco, B, Vincent, E, Tumber, A, Hulea, L, Bergeman, J, Oppermann, U, Jones, R, Laplante, M, Topisirovic, I, Petrecca, K, Huot, M, Mallette, F
Natura:	Journal article
Lingua:	English
Pubblicazione:	Springer Nature 2016

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