Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

The c-Jun N-terminal kinases (JNKs) are a group of stress-activated protein kinases that regulate gene expression changes through specific phosphorylation of nuclear transcription factor substrates. To address the mechanisms underlying JNK nuclear entry, we employed a semi-intact cell system to demo...

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Bibliographic Details
Main Authors: Misheva, M, Kaur, G, Ngoei, KRW, Yeap, YY, Ng, IHW, Wagstaff, KM, Ng, DCH, Jans, DA, Bogoyevitch, MA
Format: Journal article
Language:English
Published: Elsevier 2013