Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.

We have examined chromosomal-scale mutations in 34 large colorectal adenomas (CRAs). A small number of changes (median = 2, IQR = 0-4) were found by array-comparative genomic hybridization (aCGH) in most tumours. The most common changes were deletions of chromosomes 1p, 9q, 17, 19, and 22, and gains...

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ग्रंथसूची विवरण
मुख्य लेखकों: Jones, A, Thirlwell, C, Howarth, K, Graham, T, Chambers, W, Segditsas, S, Page, K, Phillips, R, Thomas, H, Sieber, O, Sawyer, E, Tomlinson, I
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2007

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