Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control
E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residuespecific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mech...
| Auteurs principaux: | , , , , , , , , |
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| Format: | Journal article |
| Publié: |
American Association for the Advancement of Science
2019
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