GSTM1 and GSTT1 polymorphisms as modifiers of age at diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) in a homogeneous cohort of individuals carrying a single predisposing mutation

The variability in phenotype that occurs for so-called 'single-gene disorders' may be because of germline alterations in numerous primary and "modifier" genes. Within HNPCC families harbouring the same primary predisposing mutation, differences exist in the site of cancer, age of...

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Bibliografski detalji
Glavni autori: Felix, R, Bodmer, W, Fearnhead, N, van der Merwe, L, Goldberg, P, Ramesar, R
Format: Journal article
Jezik:English
Izdano: 2006