HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy.

Histone deacetylase (HDAC) inhibitors are emergent cancer drugs. HR23B is a candidate cancer biomarker identified in a genome-wide loss-of-function screen which influences sensitivity to HDAC inhibitors. Because HDAC inhibitors have found clinical utility in cutaneous T-cell lymphoma (CTCL), we eval...

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Bibliographic Details
Main Authors: Khan, O, Fotheringham, S, Wood, V, Stimson, L, Zhang, C, Pezzella, F, Duvic, M, Kerr, D, La Thangue, N
Format: Journal article
Language:English
Published: 2010