p97/VCP regulates MRE11-dependent DNA and resection and alters cellular toxicity of ionising radiation
The ubiquitin-proteasome system (UPS) is responsible for most of the protein degradation in mammalian cells which represents a particular challenge in cancer cells that commonly have heightened protein stress. The AAA+ ATPase p97 is a central component of the UPS, where it functions in concert with...
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| Format: | Thesis |
| Language: | English |
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2021
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