The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

iRhom proteins are catalytically inactive relatives of rhomboid intramembrane proteases. There is a rapidly growing body of evidence that these pseudoenzymes have a central function in regulating inflammatory and growth factor signalling and consequent roles in many diseases. iRhom pseudoproteases h...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Dulloo, I, Muliyil, S, Freeman, M
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Royal Society 2019

Eitemau Tebyg

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases
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Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation
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Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.
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Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
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Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
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Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.
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iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction
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FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling
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FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
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Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
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The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner
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A mass spectrometry-based screen reveals FRMD8 as a novel regulator of iRhom/ADAM17-dependent inflammatory and growth factor signalling
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4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation
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Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats
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Targeting iRhom2/ADAM17 attenuates COVID-19-induced cytokine release from cultured lung epithelial cells
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iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress
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Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking
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Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.
gan: Zettl, M, et al.
Cyhoeddwyd: (2011)

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals.
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Stress-related expression of the chloroplast EGY3 pseudoprotease and its possible impact on chloroplasts’ proteome composition
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The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.
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