Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome.
The Mendelian tumour syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and hereditary paragangliomatosis with phaeochromocytomas (HPGL) result from mutations in nuclear genes (FH and SDHB/C/D, respectively) that encode Krebs cycle enzymes. HPGL tumours are highly vascular and there i...
Үндсэн зохиолчид: | Pollard, P, Wortham, N, Barclay, E, Alam, A, Elia, G, Manek, S, Poulsom, R, Tomlinson, I |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2005
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