Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

<h4>Background</h4> <p>Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO2 to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours...

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Những tác giả chính: Lee, S-H, McIntyre, D, Honess, D, Hulikova, A, Pacheco-Torres, J, Cerdán, S, Swietach, P, Harris, AL, Griffiths, JR
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Nature Publishing Group 2018