Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma

Oxaliplatin-based chemotherapy is used to treat patients with esophageal adenocarcinoma (EAC), but no biomarkers are currently available for patient selection. We performed a prospective, clinical trial to identify potential biomarkers associated with clinical outcomes. Tumor tissue was obtained fro...

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Bibliographic Details
Main Authors: MacGregor, T, Carter, R, Gillies, R, Findlay, J, Kartsonaki, C, Castro-Giner, F, Sahgal, N, Wang, L, Chetty, R, Maynard, N, Cazier, J, Buffa, F, McHugh, P, Tomlinson, I, Middleton, M, Sharma, R
Format: Journal article
Language:English
Published: Nature Publishing Group 2018