Human Semaphorin 3 variants link melanocortin circuit development and energy balance

Human Semaphorin 3 variants link melanocortin circuit development and energy balance

Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants in SEMA3A-G and their receptors (PLXNA1-4; NRP1-2) in 573 severely obes...

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Κύριοι συγγραφείς: Van Der Klaauw, AA, Croizier, S, De Oliveira, E, Stadler, LKJ, Park, S, Kong, Y, Banton, MC, Tandon, P, Hendricks, AE, Keogh, JM, Riley, SE, Papadia, S, Henning, E, Bounds, R, Bochukova, EG, Mistry, V, O'Rahilly, S, Simerly, RB, Interval, Uk10K Consortium, Minchin, JEN, Barroso, I, Jones, EY, Bouret, SG, Farooqi, IS
Μορφή: Journal article
Γλώσσα:English
Έκδοση: Elsevier 2019

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