Hepatitis C virus sequence divergence preserves p7 viroporin structural and dynamic features

The hepatitis C virus (HCV) viroporin p7 oligomerizes to form ion channels, which are required for the assembly and secretion of infectious viruses. The 63-amino acid p7 monomer has two putative transmembrane domains connected by a cytosolic loop, and has both N- and C- termini exposed to the endopl...

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Bibliographic Details
Main Authors: Oestringer, BP, Bolivar, JH, Claridge, JK, Almanea, L, Chipot, C, Dehez, F, Holzmann, N, Schnell, JR, Zitzmann, N
Format: Journal article
Published: Springer Nature 2019