Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children.
We have developed a sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS) for the simultaneous quantification of midazolam (MDZ) and its major metabolite, 1'-hydroxymidazolam (1...
Hauptverfasser: | Muchohi, SN, Ward, SA, Preston, L, Newton, C, Edwards, G, Kokwaro, G |
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Format: | Journal article |
Sprache: | English |
Veröffentlicht: |
2005
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