High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown HLA-E can present diverse peptides to NK cells and T cells, the HLA-E repertoire recognized by CD94/NKG2x has remained poorly defined, with only a limited number of peptid...

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Bibliographic Details
Main Authors: Huisman, BD, Guan, N, Rückert, T, Garner, L, Singh, NK, McMichael, AJ, Gillespie, GM, Romagnani, C, Birnbaum, ME
Format: Journal article
Language:English
Published: Springer Nature 2023