The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type h...

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Bibliographic Details
Main Authors: Muskens, IS, Li, S, Jackson, T, Elliot, N, Hansen, HM, Myint, SS, Pandey, P, Schraw, JM, Roy, R, Anguiano, J, Goudevenou, K, Siegmund, KD, Lupo, PJ, de Bruijn, MFTR, Walsh, KM, Vyas, P, Ma, X, Roy, A, Roberts, I, Wiemels, JL, de Smith, AJ
Format: Journal article
Language:English
Published: Nature 2021

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