ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: Similar functions but reciprocal effects on secretion

Closure of ATP-regulated K+ channels (KATP channels) plays a central role in glucose-stimulated insulin secretion in beta cells. KATP channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, KATP channels are open...

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Bibliographic Details
Main Authors: Rorsman, P, Ramracheya, R, Rorsman, N, Zhang, Q
Format: Journal article
Language:English
Published: Springer Verlag 2014