Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.

Antibody-mediated lysis of cells involves a complex interaction between the cell, the target antigen, the antibody and host effector mechanisms. One such mechanism, complement-mediated cell lysis, requires the interaction of C1q with the antibody heavy chain constant regions, and in particular the C...

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Autori principali: Greenwood, J, Gorman, S, Routledge, E, Lloyd, I, Waldmann, H
Natura: Journal article
Lingua:English
Pubblicazione: 1994