Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.
Antibody-mediated lysis of cells involves a complex interaction between the cell, the target antigen, the antibody and host effector mechanisms. One such mechanism, complement-mediated cell lysis, requires the interaction of C1q with the antibody heavy chain constant regions, and in particular the C...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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