Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.

Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.

Antibody-mediated lysis of cells involves a complex interaction between the cell, the target antigen, the antibody and host effector mechanisms. One such mechanism, complement-mediated cell lysis, requires the interaction of C1q with the antibody heavy chain constant regions, and in particular the C...

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Bibliografiske detaljer
Main Authors:	Greenwood, J, Gorman, S, Routledge, E, Lloyd, I, Waldmann, H
Format:	Journal article
Sprog:	English
Udgivet:	1994

Lignende værker

COMPLEMENT LYSIS MEDIATED BY ENGINEERED MULTIPLE-DOMAIN FORMS OF THE THERAPEUTIC ANTIBODY CAMPATH-1H
af: Greenwood, J, et al.
Udgivet: (1994)

Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.
af: Xia, M, et al.
Udgivet: (1993)

Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis.
af: Bindon, C, et al.
Udgivet: (1985)

Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.
af: Bindon, C, et al.
Udgivet: (1988)

Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis.
af: Xia, M, et al.
Udgivet: (1993)

A humanized monovalent CD3 antibody which can activate homologous complement.
af: Routledge, E, et al.
Udgivet: (1991)

A personal history of the CAMPATH-1H antibody.
af: Waldmann, H
Udgivet: (2002)

Reshaping a therapeutic CD4 antibody.
af: Gorman, S, et al.
Udgivet: (1991)

Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.
af: Bindon, C, et al.
Udgivet: (1987)

1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen.
af: James, L, et al.
Udgivet: (1999)

Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
af: Hale, G, et al.
Udgivet: (1986)

Specificity of monoclonal antibody Campath-1.
af: Hale, G, et al.
Udgivet: (1988)

TREATMENT OF RHEUMATOID-ARTHRITIS WITH HUMANIZED ANTILYMPHOCYTE ANTIBODY CAMPATH-1H
af: Watts, R, et al.
Udgivet: (1992)

Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
af: Isaacs, J, et al.
Udgivet: (1996)

CAMPATH-1 monoclonal antibodies in bone marrow transplantation.
af: Hale, G, et al.
Udgivet: (1994)

Availability of Campath-1 antibodies for bone marrow transplantation.
af: Hale, G, et al.
Udgivet: (1995)

The effect of aglycosylation on the immunogenicity of a humanized therapeutic CD3 monoclonal antibody.
af: Routledge, E, et al.
Udgivet: (1995)

Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H.
af: Isaacs, J, et al.
Udgivet: (1995)

CAMPATH-IH in multiple sclerosis.
af: Moreau, T, et al.
Udgivet: (1996)

CAMPATH-1H in inflammatory arthritis.
af: Watts, R, et al.
Udgivet: (1993)

CAMPATH-1 antibodies in stem-cell transplantation.
af: Hale, G, et al.
Udgivet: (2001)

EFFECTS OF MONOCLONAL-ANTIBODIES OF THE CAMPATH SERIES INVIVO - REQUIREMENTS FOR EFFECTIVE ANTIBODY THERAPY
af: Dyer, M, et al.
Udgivet: (1988)

ISOTYPE VARIANTS OF CAMPATH-1 ANTIBODY - REQUIREMENTS FOR EFFECTIVE ANTIBODY ACTION INVIVO
af: Dyer, M, et al.
Udgivet: (1989)

Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1G.
af: Williams, R, et al.
Udgivet: (2000)

Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.
af: Cheetham, G, et al.
Udgivet: (1998)

Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H.
af: Hale, G, et al.
Udgivet: (1988)

Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype.
af: Dyer, M, et al.
Udgivet: (1989)

Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.
af: Newman, D, et al.
Udgivet: (1995)

Rat monoclonal antibodies for bone marrow transplantation--the CAMPATH series.
af: Waldmann, H, et al.
Udgivet: (1985)

Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.
af: Hale, G, et al.
Udgivet: (1996)

Direct antibody rosette-forming reactions using monoclonal markers of lymphocyte subpopulations. Methodology and applications illustrated by investigations with rat pan-T antibodies of the CAMPATH series.
af: Wilson, AB, et al.
Udgivet: (1986)

RAT MONOCLONAL-ANTIBODIES FOR BONE-MARROW TRANSPLANTATION (BMT) - THE CAMPATH SERIES
af: Waldmann, H, et al.
Udgivet: (1985)

Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies.
af: Naparstek, E, et al.
Udgivet: (1999)

CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura.
af: Lim, S, et al.
Udgivet: (1993)

Reversal of allograft rejection using the monoclonal antibody, Campath-1G.
af: Friend, P, et al.
Udgivet: (1991)

CAMPATH: from concept to clinic.
af: Waldmann, H, et al.
Udgivet: (2005)

Campath-1H therapy in refractory ocular inflammatory disease.
af: Dick, A, et al.
Udgivet: (2000)

REMISSION INDUCTION IN PATIENTS WITH LYMPHOID MALIGNANCIES USING UNCONJUGATED CAMPATH-1 MONOCLONAL-ANTIBODIES
af: Dyer, M, et al.
Udgivet: (1990)

Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.
af: Isaacs, J, et al.
Udgivet: (1992)

In vivo 'purging' of residual disease in CLL with Campath-1H.
af: Dyer, M, et al.
Udgivet: (1997)