Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances
Defects in mtDNA maintenance range from fatal multisystem childhood diseases, such as Alpers syndrome, to milder diseases in adults, including mtDNA depletion syndromes (MDS) and familial progressive external ophthalmoplegia (adPEO). Most are associated with defects in genes involved in mitochondria...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2007
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| Subjects: |