Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

N(ε)-Methylations of histone lysine residues play critical roles in cell biology by "marking" chromatin for transcriptional activation or repression. Lysine demethylases reverse N(ε)-methylation in a sequence- and methylation-selective manner. The determinants of sequence selectivity for h...

書誌詳細
主要な著者:	Hillringhaus, L, Yue, W, Rose, N, Ng, S, Gileadi, C, Loenarz, C, Bello, S, Bray, J, Schofield, C, Oppermann, U
フォーマット:	Journal article
言語:	English
出版事項:	2011

類似資料

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
著者:: Ng, S, 等
出版事項: (2007)

Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
著者:: Tarhonskaya, H, 等
出版事項: (2017)

Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
著者:: Walport, L, 等
出版事項: (2014)

Structural analysis of human KDM5B guides histone demethylase inhibitor development.
著者:: Johansson, C, 等
出版事項: (2016)

Conformational dynamics underlies different functions of human KDM7 histone demethylases
著者:: Chaturvedi, S, 等
出版事項: (2019)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
著者:: Rose, N, 等
出版事項: (2008)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
著者:: Rose, N, 等
出版事項: (2008)

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
著者:: Woon, E, 等
出版事項: (2012)

Human histone demethylase KDM6B can catalyse sequential oxidations
著者:: Hopkinson, R, 等
出版事項: (2018)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
著者:: Sakurai, M, 等
出版事項: (2010)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
著者:: Sakurai, M, 等
出版事項: (2010)

The nuclear bodies formed by histone demethylase KDM7A
著者:: Hui Ming, 等
出版事項: (2020-09-01)

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
著者:: Rose, N, 等
出版事項: (2012)

Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control
著者:: Ramanan, R, 等
出版事項: (2020)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
著者:: Kawamura, A, 等
出版事項: (2010)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
著者:: Kawamura, A, 等
出版事項: (2010)

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.
著者:: Thalhammer, A, 等
出版事項: (2011)

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.
著者:: Thalhammer, A, 等
出版事項: (2011)

Investigating the substrate selectivity and the inhibitor of the human KDM7 sub-family of JmjC histone lysine demethylases
著者:: Zhang, Y
出版事項: (2019)

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
著者:: Suzuki, T, 等
出版事項: (2013)

KDM5 histone demethylases repress immune response via suppression of STING.
著者:: Lizhen Wu, 等
出版事項: (2018-08-01)

The histone demethylase Kdm5 controls Hid-induced cell death in Drosophila
著者:: Hans-Martin Herz, 等
出版事項: (2024-11-01)

Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells
著者:: Liangtang Wu, 等
出版事項: (2015-07-01)

Histone Lysine Demethylases KDM5B and KDM5C Modulate Genome Activation and Stability in Porcine Embryos
著者:: Werner Giehl Glanzner, 等
出版事項: (2020-03-01)

Exploring the substrate scope of histone demethylases
著者:: Bonnici, J
出版事項: (2020)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
著者:: Chowdhury, R, 等
出版事項: (2011)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
著者:: Chowdhury, R, 等
出版事項: (2011)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
著者:: Chowdhury, R, 等
出版事項: (2011)

Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer.
著者:: Yang, J, 等
出版事項: (2018)

Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A
著者:: Hancock, R
出版事項: (2016)

Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance
著者:: Guo-Qing Chen, 等
出版事項: (2020-01-01)

A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5
著者:: Sumaira Zamurrad, 等
出版事項: (2018-02-01)

Sexually Dimorphic Alterations in the Transcriptome and Behavior with Loss of Histone Demethylase <i>KDM5C</i>
著者:: Katherine M. Bonefas, 等
出版事項: (2023-02-01)

Structure and mechanism guided identification of histone demethylase inhibitors
著者:: Schofield, C
出版事項: (2010)

Advances and challenges in understanding histone demethylase biology
著者:: Nowak, R, 等
出版事項: (2016)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
著者:: Pollard, P, 等
出版事項: (2008)

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor
著者:: England, K, 等
出版事項: (2014)

Mechanisms of human histone and nucleic acid demethylases
著者:: Walport, L, 等
出版事項: (2012)

Mechanisms of human histone and nucleic acid demethylases.
著者:: Walport, L, 等
出版事項: (2012)

The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system
著者:: Mohamed Reda Fazazi, 等
出版事項: (2023-10-01)