Artificial mirtron-mediated gene knockdown: functional DMPK silencing in mammalian cells.
Mirtrons are introns that form pre-miRNA hairpins after splicing to produce RNA interference (RNAi) effectors distinct from Drosha-dependent intronic miRNAs. Here we present a design algorithm for artificial mirtrons and demonstrate, for the first time, efficient gene knockdown of myotonic dystrophy...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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