Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To...

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主要な著者: Lange, L, Hu, Y, Zhang, H, Xue, C, Schmidt, E, Tang, Z, Bizon, C, Lange, E, Smith, J, Turner, E, Jun, G, Kang, H, Peloso, G, Auer, P, Li, K, Flannick, J, Zhang, J, Fuchsberger, C, Gaulton, K, Lindgren, C, Locke, A, Manning, A, Sim, X, Rivas, M, Holmen, O, Gottesman, O, Lu, Y, Ruderfer, D, Stahl, E, Duan, Q, Li, Y, Durda, P, Jiao, S, Isaacs, A, Hofman, A, Bis, J, Correa, A, Griswold, M, Jakobsdottir, J, Smith, A, Schreiner, P, Feitosa, M, Zhang, Q, Huffman, J, Crosby, J, Wassel, C, Do, R, Franceschini, N, Martin, L, Robinson, J, Assimes, T, Crosslin, DR, Rosenthal, E, Tsai, M, Rieder, M, Farlow, D, Folsom, A, Lumley, T, Fox, E, Carlson, C, Peters, U, Jackson, R, van Duijn, C, Uitterlinden, A, Levy, D, Rotter, J, Taylor, H, Gudnason, V, Siscovick, D, Fornage, M, Borecki, I, Hayward, C, Rudan, I, Chen, Y, Bottinger, E, Loos, R, Sætrom, P, Hveem, K, Boehnke, M, Groop, L, McCarthy, M, Meitinger, T, Ballantyne, C, Gabriel, S, O'Donnell, C, Post, W, North, K, Reiner, A, Boerwinkle, E, Psaty, B, Altshuler, D, Kathiresan, S, Lin, D, Jarvik, G, Cupples, L, Kooperberg, C, Wilson, J, Nickerson, D, Abecasis, G, Rich, S, Tracy, R, Willer, C
フォーマット: Journal article
言語:English
出版事項: Cell Press 2014

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