Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To...

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Main Authors: Lange, L, Hu, Y, Zhang, H, Xue, C, Schmidt, E, Tang, Z, Bizon, C, Lange, E, Smith, J, Turner, E, Jun, G, Kang, H, Peloso, G, Auer, P, Li, K, Flannick, J, Zhang, J, Fuchsberger, C, Gaulton, K, Lindgren, C, Locke, A, Manning, A, Sim, X, Rivas, M, Holmen, O, Gottesman, O, Lu, Y, Ruderfer, D, Stahl, E, Duan, Q, Li, Y, Durda, P, Jiao, S, Isaacs, A, Hofman, A, Bis, J, Correa, A, Griswold, M, Jakobsdottir, J, Smith, A, Schreiner, P, Feitosa, M, Zhang, Q, Huffman, J, Crosby, J, Wassel, C, Do, R, Franceschini, N, Martin, L, Robinson, J, Assimes, T, Crosslin, DR, Rosenthal, E, Tsai, M, Rieder, M, Farlow, D, Folsom, A, Lumley, T, Fox, E, Carlson, C, Peters, U, Jackson, R, van Duijn, C, Uitterlinden, A, Levy, D, Rotter, J, Taylor, H, Gudnason, V, Siscovick, D, Fornage, M, Borecki, I, Hayward, C, Rudan, I, Chen, Y, Bottinger, E, Loos, R, Sætrom, P, Hveem, K, Boehnke, M, Groop, L, McCarthy, M, Meitinger, T, Ballantyne, C, Gabriel, S, O'Donnell, C, Post, W, North, K, Reiner, A, Boerwinkle, E, Psaty, B, Altshuler, D, Kathiresan, S, Lin, D, Jarvik, G, Cupples, L, Kooperberg, C, Wilson, J, Nickerson, D, Abecasis, G, Rich, S, Tracy, R, Willer, C
格式: Journal article
語言:English
出版: Cell Press 2014

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