Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism

Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism

Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making t...

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Bibliographic Details
Main Authors: Chong, T, Bonnelle, V, Veromann, K, Juurmaa, J, Taba, P, Plant, O, Husain, M
Format: Journal article
Published: Wiley 2017
Description
Summary:Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.

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