Stereoselective reduction of chiral 2-furoic acid derivatives using group I metals in ammonia

A series of chiral auxiliaries have been attached to 2-furoic acid and 3-methyl-2-furoic acid. The performance of these auxiliaries in the Birch reduction was assessed and it was found that placing a C-3 methyl group on the heterocycle was essential for good stereoselectivity. Using bis(methoxymethy...

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Bibliographic Details
Main Authors: Donohoe, T, Calabrese, A, Stevenson, C, Ladduwahetty, T
Format: Journal article
Language:English
Published: 2000