Targeting BRCA2 deficiency with GSK3 inhibitors
<p>BRCA1 and BRCA2 tumour suppressors are essential for homologous recombination-mediated double-strand break repair and replication fork protection. Therefore, BRCA1 and BRCA2 are essential for cell viability. Deactivating mutations in one of these genes lead to genome instability and are ass...
المؤلف الرئيسي: | Zonderland, G |
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مؤلفون آخرون: | Tarsounas, M |
التنسيق: | أطروحة |
منشور في: |
2017
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مواد مشابهة
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Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance
حسب: Tacconi, E, وآخرون
منشور في: (2019) -
Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance
حسب: Eliana MC Tacconi, وآخرون
منشور في: (2019-05-01) -
Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds
حسب: Zimmer, J, وآخرون
منشور في: (2016) -
Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights
حسب: Ashwin Ragupathi, وآخرون
منشور في: (2023-03-01) -
Novel approaches for targeting BRCA2-deficient tumour cells
حسب: Tacconi, E
منشور في: (2015)