Targeting BRCA2 deficiency with GSK3 inhibitors

Targeting BRCA2 deficiency with GSK3 inhibitors

<p>BRCA1 and BRCA2 tumour suppressors are essential for homologous recombination-mediated double-strand break repair and replication fork protection. Therefore, BRCA1 and BRCA2 are essential for cell viability. Deactivating mutations in one of these genes lead to genome instability and are ass...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Zonderland, G
Rannpháirtithe:	Tarsounas, M
Formáid:	Tráchtas
Foilsithe / Cruthaithe:	2017

Míreanna comhchosúla

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance
de réir: Tacconi, E, et al.
Foilsithe / Cruthaithe: (2019)

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance
de réir: Eliana MC Tacconi, et al.
Foilsithe / Cruthaithe: (2019-05-01)

Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds
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Foilsithe / Cruthaithe: (2016)

Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights
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Foilsithe / Cruthaithe: (2023-03-01)

Novel approaches for targeting BRCA2-deficient tumour cells
de réir: Tacconi, E
Foilsithe / Cruthaithe: (2015)

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
de réir: Ilirjana Bajrami, et al.
Foilsithe / Cruthaithe: (2021-11-01)

GSK-3 inhibitors induce chromosome instability
de réir: Staples Oliver D, et al.
Foilsithe / Cruthaithe: (2007-08-01)

A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
de réir: Rebecca A. Dagg, et al.
Foilsithe / Cruthaithe: (2021-08-01)

Lithium and Therapeutic Targeting of GSK-3
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Foilsithe / Cruthaithe: (2021-01-01)

The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment
de réir: Giuseppa Augello, et al.
Foilsithe / Cruthaithe: (2020-06-01)

Targeting GPX4-mediated ferroptosis protection sensitizes BRCA1-deficient cancer cells to PARP inhibitors
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Foilsithe / Cruthaithe: (2024-10-01)

Machine Learning for Discovery of GSK3β Inhibitors
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Foilsithe / Cruthaithe: (2020-10-01)

GSK-3 inhibitors: preclinical and clinical focus on CNS
de réir: Hagit eEldar-Finkelman, et al.
Foilsithe / Cruthaithe: (2011-10-01)

GSK-3 Inhibitors and Tooth Repair: An Ethical Analysis
de réir: Sorin Hostiuc, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Sustained delivery of PARP inhibitor Talazoparib for the treatment of BRCA-deficient ovarian cancer
de réir: Shicheng Yang, et al.
Foilsithe / Cruthaithe: (2023-05-01)

A Novel PARP Inhibitor YHP-836 For the Treatment of BRCA-Deficiency Cancers
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Foilsithe / Cruthaithe: (2022-07-01)

PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting
de réir: Karolina N. Dziadkowiec, et al.
Foilsithe / Cruthaithe: (2017-02-01)

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.
de réir: Tacconi, E, et al.
Foilsithe / Cruthaithe: (2017)

Identification of a RAD52 Inhibitor Inducing Synthetic Lethality in BRCA2-Deficient Cancer Cells
de réir: Qianye Yang, et al.
Foilsithe / Cruthaithe: (2021-04-01)

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
de réir: Zatreanu, D, et al.
Foilsithe / Cruthaithe: (2021)

Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β.
de réir: Young Ou, et al.
Foilsithe / Cruthaithe: (2012-01-01)

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
de réir: Eliana MC Tacconi, et al.
Foilsithe / Cruthaithe: (2017-07-01)

Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
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Foilsithe / Cruthaithe: (2023-04-01)

The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells
de réir: Ata ur Rahman Mohammed Abdul, et al.
Foilsithe / Cruthaithe: (2018-01-01)

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
de réir: Diana Zatreanu, et al.
Foilsithe / Cruthaithe: (2021-06-01)

The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis
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Foilsithe / Cruthaithe: (2016-03-01)

Novel reporter alleles of GSK-3α and GSK-3β.
de réir: William B Barrell, et al.
Foilsithe / Cruthaithe: (2012-01-01)

Correction: Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
de réir: Julieta Martino, et al.
Foilsithe / Cruthaithe: (2023-11-01)

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer
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BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy
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GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer.
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Foilsithe / Cruthaithe: (2016-01-01)

Intrinsic resistance of HIV-2 and SIV to the maturation inhibitor GSK2838232
de réir: Robert A. Smith, et al.
Foilsithe / Cruthaithe: (2023-01-01)

Intrinsic resistance of HIV-2 and SIV to the maturation inhibitor GSK2838232.
de réir: Robert A Smith, et al.
Foilsithe / Cruthaithe: (2023-01-01)

Glycogen synthase kinase 3 (GSK-3) and its inhibitors : drug discovery and development /
de réir: Martinez, Ana, 1961-, et al.
Foilsithe / Cruthaithe: (2006)

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
de réir: Xia Ding, et al.
Foilsithe / Cruthaithe: (2016-08-01)

1111 Targeting lipid metabolism to improve PARP inhibitor response in BRCA-associated TNBC
de réir: Geoffrey I Shapiro, et al.
Foilsithe / Cruthaithe: (2023-11-01)

BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2.
de réir: Melissa S Cline, et al.
Foilsithe / Cruthaithe: (2018-12-01)

Role of GSK-3β Inhibitors: New Promises and Opportunities for Alzheimer’s Disease
de réir: Suggala Ramya Shri, et al.
Foilsithe / Cruthaithe: (2023-11-01)

Discovery of Novel Imidazopyridine GSK-3β Inhibitors Supported by Computational Approaches
de réir: Rosa Buonfiglio, et al.
Foilsithe / Cruthaithe: (2020-05-01)

Computational study of some cancer drugs as potent inhibitors of GSK3β
de réir: David Ebuka Arthur, et al.
Foilsithe / Cruthaithe: (2020-11-01)