Targeting BRCA2 deficiency with GSK3 inhibitors
<p>BRCA1 and BRCA2 tumour suppressors are essential for homologous recombination-mediated double-strand break repair and replication fork protection. Therefore, BRCA1 and BRCA2 are essential for cell viability. Deactivating mutations in one of these genes lead to genome instability and are ass...
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| Materialtyp: | Lärdomsprov |
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2017
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