A spontaneous ring-opening reaction leads to a repair‐resistant thymine oxidation product in genomic DNA

The alphabet of modified DNA bases goes beyond the conventional four letters, with biological roles being found for many such modifications. Herein, we describe the observation of a modified thymine base that arises from spontaneous N1−C2 ring opening of the oxidation product 5‐formyl uracil, after...

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Detalhes bibliográficos
Principais autores: Sahakyan, A, Mahtey, A, Kawasaki, F, Balasubramanian, S
Formato: Journal article
Idioma:English
Publicado em: Wiley 2019