Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

ADP ribosylation is a reversible posttranslational modification mediated by poly(ADP-ribose)transferases (e.g., PARP1) and (ADP-ribosyl)hydrolases (e.g., ARH3 and PARG), ensuring synthesis and removal of mono-ADP-ribose or poly-ADP-ribose chains on protein substrates. Dysregulation of ADP ribosylati...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Beijer, D, Agnew, T, Rack, JGM, Prokhorova, E, Deconinck, T, Ceulemans, B, Peric, S, Milic Rasic, V, De Jonghe, P, Ahel, I, Baets, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Life Science Alliance, LLC 2021

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gan: Palazzo, L, et al.
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gan: Munnur, D, et al.
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gan: Pietro Fontana, et al.
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gan: Bartlett, E, et al.
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HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity
gan: Gibbs-Seymour, I, et al.
Cyhoeddwyd: (2016)

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gan: Rack, JGM, et al.
Cyhoeddwyd: (2021)

Reversible mono-ADP-ribosylation of DNA breaks.
gan: Munnur, D, et al.
Cyhoeddwyd: (2017)

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gan: Palazzo, L, et al.
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Monitoring poly(ADP-ribosyl)glycohydrolase activity with a continuous fluorescent substrate
gan: Drown, B, et al.
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gan: Palazzo, L, et al.
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gan: Agnew, T, et al.
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Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA
gan: Hloušek-Kasun, A, et al.
Cyhoeddwyd: (2022)

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria
gan: Thomas Agnew, et al.
Cyhoeddwyd: (2018-01-01)

(ADP-ribosyl)hydrolases: Structural basis for differential substrate recognition and inhibition
gan: Rack, J, et al.
Cyhoeddwyd: (2018)

Investigating the role of serine-ADP-ribosylation in human cells
gan: Prokhorova, E
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Specificity of DNA ADP-Ribosylation Reversal by NADARs
gan: Bara Cihlova, et al.
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Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites.
gan: Matic, I, et al.
Cyhoeddwyd: (2012)

Beyond protein modification: the rise of non-canonical ADP-ribosylation
gan: Schuller, M, et al.
Cyhoeddwyd: (2022)

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
gan: Suskiewicz, MJ, et al.
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gan: Johannes Gregor Matthias Rack, et al.
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Specificity of reversible ADP-ribosylation and regulation of cellular processes
gan: Crawford, K, et al.
Cyhoeddwyd: (2017)

Serine ADP-ribosylation reversal by the hydrolase ARH3
gan: Fontana, P, et al.
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Serine ADP-Ribosylation Depends on HPF1
gan: Bonfiglio, J, et al.
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Serine ADP-ribosylation reversal by the hydrolase ARH3
gan: Pietro Fontana, et al.
Cyhoeddwyd: (2017-06-01)

Viral macro domains reverse protein ADP-ribosylation.
gan: Li, C, et al.
Cyhoeddwyd: (2016)

Reversing ADP-ribosylation
gan: Giuliana Katharina Moeller, et al.
Cyhoeddwyd: (2017-08-01)

Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens
gan: Rack, J, et al.
Cyhoeddwyd: (2015)

Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity
gan: Kong, L, et al.
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Synthetic α- and β-Ser-ADP-ribosylated peptides reveal α-Ser-ADPr as the native epimer
gan: Voorneveld, J, et al.
Cyhoeddwyd: (2018)

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
gan: Kar, P, et al.
Cyhoeddwyd: (2024)

Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
gan: Rocco Caggiano, et al.
Cyhoeddwyd: (2025-01-01)

ENPP1 processes protein ADP-ribosylation in vitro.
gan: Palazzo, L, et al.
Cyhoeddwyd: (2016)

Arginine-specific mono ADP-ribosylation in vitro of antimicrobial peptides by ADP-ribosylating toxins.
gan: Marta Castagnini, et al.
Cyhoeddwyd: (2012-01-01)

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gan: Ariza, A, et al.
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DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
gan: Zhu, K, et al.
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