Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
BACKGROUND and AIMS: According to the somatic mutation theory, monoclonal colorectal lesions arise from sequential mutations in the progeny of a single stem cell. However, studies in a sex chromosome mixoploid mosaic (XO/XY) patient indicated that colorectal adenomas were polyclonal. We assessed ade...
| Main Authors: | , , , , , , , , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
2010
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