Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.

Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.

BACKGROUND and AIMS: According to the somatic mutation theory, monoclonal colorectal lesions arise from sequential mutations in the progeny of a single stem cell. However, studies in a sex chromosome mixoploid mosaic (XO/XY) patient indicated that colorectal adenomas were polyclonal. We assessed ade...

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Bibliographic Details
Main Authors: Thirlwell, C, Will, O, Domingo, E, Graham, T, McDonald, SA, Oukrif, D, Jeffrey, R, Gorman, M, Rodriguez-Justo, M, Chin-Aleong, J, Clark, S, Novelli, MR, Jankowski, J, Wright, N, Tomlinson, I, Leedham, S
Format: Journal article
Language:English
Published: 2010

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