A general copper-catalyzed synthesis of Ynamides from 1,2-dichloroenamides

Ynamides are accessed via copper-catalyzed coupling of Grignard or organozinc nucleophiles with chloroynamides, formed in situ from 1,2-dichloroenamides. The reaction exhibits a broad substrate scope, is readily scaled, and overcomes typical limitations in ynamide synthesis such as the use of ureas,...

詳細記述

書誌詳細
主要な著者: Mansfield, S, Smith, R, Yong, J, Garry, O, Anderson, E
フォーマット: Journal article
言語:English
出版事項: American Chemical Society 2019