Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Post-translational histone modification has a fundamental role in chromatin biology and is proposed to constitute a 'histone code' in epigenetic regulation. Differential methylation of histone H3 and H4 lysyl residues regulates processes including heterochromatin formation, X-chromosome in...

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Dettagli Bibliografici
Autori principali: Ng, S, Kavanagh, K, McDonough, M, Butler, D, Pilka, E, Lienard, B, Bray, J, Savitsky, P, Gileadi, O, von Delft, F, Rose, N, Offer, J, Scheinost, J, Borowski, T, Sundstrom, M, Schofield, C, Oppermann, U
Natura: Journal article
Lingua:English
Pubblicazione: 2007