Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cell...

书目详细资料
Main Authors:	Markkanen, E, Fischer, R, Ledentcova, M, Kessler, B, Dianov, G
格式:	Journal article
语言:	English
出版:	Oxford University Press 2015

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