IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide
Prior studies implicate type 1 IGF receptor (IGF-1R) in mediating chemo-resistance. Here, we investigated whether IGF-1R influences response to temozolomide (TMZ), which generates DNA adducts that are removed by O6-methylguanine-DNA methyltransferase (MGMT), or persist causing replication-associate...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Impact Journals
2015
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