Sperm express a Ca2+-regulated NAADP synthase.

Sperm express a Ca2+-regulated NAADP synthase.

NAADP (nicotinic acid-adenine dinucleotide phosphate), the most potent Ca2+-mobilizing second messenger, is active in a wide range of organisms and cell types. Until now, all NAADP-producing enzymes have been thought to be members of the ADP-ribosyl cyclase family. ADP-ribosyl cyclases exhibit promi...

Bibliográfalaš dieđut
Váldodahkkit:	Vasudevan, SR, Galione, A, Churchill, G
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2008

Geahča maid

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Regulation and pathway of NAADP synthesis in sea urchin sperm
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Coordination of Ca2+ signalling by NAADP.
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Sperm deliver a new second messenger: NAADP.
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Calcium stimulates the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) in sea urchin sperm
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NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.
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Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand.
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Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.
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NAADP controls cross-talk between distinct Ca2+ stores in the heart.
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NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells.
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Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).
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NAADP-induced calcium release in sea urchin eggs.
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NAADP regulates human platelet function.
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The luminal Ca2+ chelator, TPEN, inhibits NAADP-induced Ca2+ release
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The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.
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Chemical synthesis of the novel Ca2+ messenger NAADP.
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NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.
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NAADP receptors.
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NAADP Receptors
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NAADP receptors
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Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.
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NAADP induces pH changes in the lumen of acidic Ca2+ stores.
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Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).
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Identification of a chemical probe for NAADP by virtual screening.
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NAADP receptors.
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The Involvement of NAADP and Two-Pore Ca2+ Channels in the Cardiac Beta-Adrenergic Response
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The NAADP receptor: new receptors or new regulation?
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NAADP: a novel Ca2+ mobilizing messenger during beta-adrenoceptor stimulation in guinea-pig ventricular myocytes
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Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals
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Synthesis, degradation, binding and actions of NAADP in cardiac tissue.
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Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate.
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Rapid, selective and dose-dependent elevation of the second messenger NAADP
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A novel signalling role for NAADP in arterial smooth muscle
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NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca2+ nanodomains, calcineurin and dynamin
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Almmustuhtton: (2020)

Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells.
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