When should factorial designs be used for late-phase randomised controlled trials?

<p><b>Background</b></p> A 2×2 factorial design evaluates two interventions (A versus control and B versus control) by randomising to control, A-only, B-only or both A and B together. Extended factorial designs are also possible (e.g. 3×3 or 2×2×2). Factorial designs often re...

Full description

Bibliographic Details
Main Authors: White, IR, Szubert, AJ, Choodari-Oskooei, B, Walker, AS, Parmar, MKB
Format: Journal article
Language:English
Published: SAGE Publications 2023