The emerging role of Mule and ARF in the regulation of base excision repair.
The ARF (Alternative Reading Frame) protein is encoded in the Ink4a locus of human chromosome 9 that is frequently mutated in cancer cells. It was recently demonstrated that ARF is induced in response to DNA damage and inhibits, by direct interaction, the E3 ubiquitin ligase Mule that regulates p53...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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