A common variant at the 14q32 endometrial cancer risk locus activates AKT1 through YY1 binding

A common variant at the 14q32 endometrial cancer risk locus activates AKT1 through YY1 binding

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A recent meta-analysis of multiple genome-wide association and follow-up endometrial cancer case-control datasets identified a novel genetic risk locus for this disease at chromosome 14q32.33. To prioritize the functional SNP(s) and target gene(s) at this locus, we employed an in silico fine-mapping...

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Hlavní autoři: Painter, J, Kaufmann, S, O'Mara, T, Hillman, K, Sivakumaran, H, Darabi, H, Cheng, T, Pearson, J, Kazakoff, S, Waddell, N, Hoivik, E, Goode, E, Scott, R, Tomlinson, I, Dunning, A, Easton, D, French, J, Salvesen, H, Pollock, P, Thompson, D, Spurdle, A, Edwards, S
Médium: Journal article
Jazyk:English
Vydáno: Cell Press 2016

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