SNM1A is crucial for efficient repair of complex DNA breaks in human cells

DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to completion of DSB repair, the chemically modified termini must be...

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Bibliographic Details
Main Authors: Swift, L, Lagerholm, B, Henderson, L, Ratnaweera, M, Baddock, HT, Sengerova, B, Lee, S, Cruz-Migoni, A, Waithe, D, Renz, C, Ulrich, HD, Newman, J, Schofield, C, McHugh, P
Format: Journal article
Language:English
Published: Springer Nature 2024